PLRP-S Prep to Process
PLRP-S Prep to Process from Agilent Technologies
The PLRP-S media, rigid poly(styrene/divinylbenzene) particles, are available in a range of pore sizes for small molecule, synthetic biomolecule and macromolecule purification. Their thermal and chemical stability makes them ideal for purifications that require extreme conditions for sample preparation, compound elution, and column regeneration.
Capacity and resolution are two key parameters for maximizing the throughput of a purification. With a wide choice of pore sizes and extended range of operating conditions, PLRP-S provides more options to achieve the optimum process. Particle sizes range from 3 µm to 50 µm for scale-up from the µg/mg discovery stage to multi-kg cGMP production. Excellent chemical stability, up to 1 M NaOH, permits sanitation and regeneration that increase column lifetime. PLRP-S media batch sizes of up to 600 L are available, providing single batch packing of multiple columns.
All pictures shown are for illustration purpose only. Actual product may vary.
- Buy
- Features
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- Discovery stage to multi-kg cGMP production reduces method development time
- Chemical stability for separations, optimization, sanitation, and regeneration increases selectivity and column lifetime
- Single batch packing of multiple columns reduces system downtime and validation costs
- Specifications
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PLRP-S Prep to Process Application Guide
Pore Size Application 100 Å 300 Å 1000 Å 4000 Å Synthetic biomolecules, peptides, and oligonucleotides ✔ ✔ Recombinant biomolecules, peptides, and proteins ✔ ✔ Large biomolecules, antibodies, DNA fragments ✔ ✔ Small molecules, unstable compounds including metal sensitivity ✔ PLRP-S Specifications
PLRP-S pH Range 1 - 14 Buffer Content Unlimited Organic Modifier 1 - 100% Temperature Limits 200 °C Maximum Pressure 5 - 8 µm: 3000 psi (210 bar) - Literature
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Prep Columns Brochure
Overview of Agilent's range of prep column for small molecules and biomolecules
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PLRP-S Data Sheet
Data sheet for the PLRP-S polymeric reversed-phase columns
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PLRP-S Technical Overview
Technical overview of the PLRP-S polymeric reversed-phase columns
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PLRP-S Protein Purification Brochure
Provides the key benefits of the PLRP-S columns for small peptides and oligonucleotides through to large proteins analysis
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